Articles on Zolidd® or Prototype

Randomised trial of bisphosphonate-coated implant: Radiograpic follow-up after 5 years of loading.
Abtahi J, Henefalk G, Aspenberg P, Int J Oral Maxillofac Surg. Dec 2016 ;45, (12), 1564–1569
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Early tissue responses to zoledronate, locally delivered by bone screw, into a compromised cancellous bone site: a pilot study.
Arnoldi J. Alves A, Procter P. BMC Musculoskeletal Disorders 2014, 15:97
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Bisphosphonate-coated external fixation pins appear similar to hydroxyapatite-coated pins in the tibial metaphysis and to uncoated pins in the shaft.
Toksvig-Larsen S and Aspenberg P Acta Orthop (Toksvig-Larsen e Aspenberg, 2013)
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Effect of Local vs. Systemic Bisphosphonate Delivery on Dental Implant Fixation in a Model of Osteonecrosis of the Jaw.
Abtahi J, Agholme F, Sandberg O, Aspenberg PJ Dent Res; Dec 2013 92(3):279-283
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Bisphosphonate-induced osteonecrosis of the jaw in a rat model arises first after the bone has become exposed. No primary necrosis in unexposed bone.
Abtahi J, Agholme F, Sandberg O, Aspenberg P, J Oral Pathol Med. 2012 Jul;41(6):494-9
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A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants.
Abtahi J, Tengvall P, Aspenberg P, Bone. 2012 May;50(5):1148-51
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Bisphosphonate coating might improve fixation of dental implants in the maxilla: a pilot study
Abtahi J, Tengvall P, Aspenberg P, Int J Oral Maxillofac Surg. 2010 Jul;39(7):673-7. Epub 2010 May 7
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Local bisphosphonate release versus hydroxyapatite coating for stainless steel screw fixation in rat tibia.
Agholme F, Andersson T, Tengvall P, Aspenberg P, J Mater Sci Mater Med. 2012 Mar; 23(3):743-52
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Surface immobilized zoledronate improves screw fixation in rat bone: a new method for the coating of metal implants.
Andersson T, Agholme F, Aspenberg P, Tengvall P, J Mater Sci Mater Med. 2010 Nov;21(11):3029-37. Epub 2010 Sep 21
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In vivo assessment of local effects after application of bone screws delivering bisphosphonates into a compromised cancellous bone site
Roshan-Ghias A, Arnoldi J, Procter P, Pioletti DP, Clin Biomech (Bristol, Avon). 2011 Dec;26(10):1039-43
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Surface immobilized bisphosphonate improves stainless-steel screw fixation in rat
Tengvall P, Skoglund B, Askendal A, Aspenberg P, Biomaterials 25 (2004) 2133–2138
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Bisphosphonate coating on titanium screws increases mechanical fixation in rat tibia after two week
Wermelin K, Aspenberg P, Linderbäck P, Tengvall P, J Biomed Mater Res A. 2008 Jul; 86(1):220-7
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Stainless steel screws coated with bisphosphonates gave stronger fixation and more surrounding bone. Histomorphometry in rats
Wermelin K, Suska F, Tengvall P, Thomsen P, Aspenberg P, Bone. 2008 Feb;42(2):365-71
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Surface-bound bisphosphonates enhance screw fixation in rats - increasing effect up to 8 weeks after insertion
Wermelin K, Tengvall P, Aspenberg P, Acta Orthop. 2007 Jun; 78(3):385-92
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