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Local bisphosphonates in human study show...

External fixation pins tend to loosen with time, especially from cancellous bone. A coating that releases a bisphosphonate has previously shown to improve the fixation of dental implants in humans. In this study bisphosphonate coating on steel pins were tested for external fixation. The results suggest that a bisphosphonate coating enables metaphyseal fixation with no difference from uncoated pins in cortical bone.

Bisphosphonate-coated external fixation pins appear similar to hydroxyapatite-coated pins in the tibial metaphysis and to uncoated pins in the shaft, Toksvig-Larsen S and Aspenberg P Acta Orthop  2013

Article on PubMed