No risk for ONJ with local delivery of bisphosphonates
The study showed that local treatment of bisphosphonate treatment appears to improve implant fixation in a setting where systemic treatment caused osteonecrosis of the jaw (ONJ). Implant removal torque was higher for the bisphosphonate-coated implants compared with the other groups, meaning stronger bone, better fixation, around the implant. Micro-computed tomography of the maxilla also showed more bone loss in the systemic alendronate group compared with groups receiving local treatment, thou a better fixation with less side effects are achieved by local instead of systemic distribution of the bisphosphonate drugs.
Effect of Local vs. Systemic Bisphosphonate Delivery on Dental Implant Fixation in a Model of Osteonecrosis of the Jaw, Abtahi J, Agholme F, Sandberg O, Aspenberg PJ Dent Res; Dec 2013 92(3):279-283